Six new regional health areas are expected to be fully operational by early 2024.
Regional structures will be set up within the HSE, which will continue to act as a national centre providing highly specialised services.
Full implementation details will be established later this year, before recruiting for posts within the new RHA's starts in 2023.
Sinn Fein's health spokesperson, Waterford TD David Cullinane, says radical change in the HSE is needed for this to work.
"We do need a centre in the HSE, of course we do, and we need proper clinical governance.
"But you can do that and give guidelines but then transfer and devolve the responsibility in key areas like recruitment, capital processes and procurement and all of those issues, which takes far too long."
