The Irish team to face Wales this Saturday has been announced.
Sexton makes his seasonal debut and is joined by Murray.
Earls also makes his return for the final game before the Rugby World Cup kicks off later this month.
Saturday also marks Joe Schmidt's final home game in charge.
It is a much-changed team from the one that secured a narrow victory over the Welsh side last week.
15. Rob Kearney
14. Jordan Larmour
13. Robbie Henshaw
12. Bundee Aki
11. Keith Earls
10. Jonathan Sexton
9. Conor Murray
1. Cian Healy
2. Rory Best CAPTAIN
3. Tadhg Furlong
4. James Ryan
5. Jean Kleyn
6. CJ Stander
7. Josh van der Flier
8. Jack Conan
Replacements
16. Sean Cronin
17. Dave Kilcoyne
18. Andrew Porter
19. Iain Henderson
20. Rhys Ruddock
21. Luke McGrath
22. Jack Carty
23. Garry Ringrose
